There were 45 registrations between 25/3/2022 and 1/4/2022. There were also 15 deregistrations. These have been coordinated by the NWCFL League Registrations Secretary, Rob Goodwin-Davey.
| Club | Player Name | Date Registered | Reg Type | Role |
| Atherton LR | Tom Heyes | Saturday 26th March 2022 | Non Contract | |
| Avro | Xavaiae Myers | Friday 25th March 2022 | Non Contract | |
| Avro | Lloyd Smith | Monday 28th March 2022 | Non Contract | |
| Avro | Angus Taylor | Friday 25th March 2022 | Non Contract | |
| Bacup Borough | Daniel Cocks | Friday 25th March 2022 | Non Contract | |
| Bacup Borough | Morgan Lang | Thursday 31st March 2022 | Non Contract | |
| Burscough | Tolani Omotola | Friday 25th March 2022 | Non Contract | |
| Campion | Lee Ashforth | Saturday 26th March 2022 | Non Contract | |
| Cleator Moor Celtic | Ben McCarron | Monday 28th March 2022 | Non Contract | |
| Congleton Town | Oliver Griffiths | Monday 28th March 2022 | Non Contract | |
| Eccleshall | Ethan Stanton | Friday 25th March 2022 | Non Contract | |
| Ellesmere Rangers | William Evans | Friday 25th March 2022 | Non Contract | |
| Holker Old Boys | Tyler Wood | Tuesday 29th March 2022 | Non Contract | |
| Irlam | Louis Haddock | Friday 25th March 2022 | Non Contract | |
| Irlam | George Lindo | Friday 25th March 2022 | Non Contract | |
| Longridge Town | Thomas Turner | Wednesday 30th March 2022 | Non Contract | |
| Lower Breck | Oscar Billington | Wednesday 30th March 2022 | Non Contract | |
| Lower Breck | Jabril Jan | Saturday 26th March 2022 | Non Contract | |
| Lower Breck | Jonathon Swatton | Monday 28th March 2022 | Non Contract | |
| Lower Breck | Jay Webb | Monday 28th March 2022 | Non Contract | |
| Maine Road | Francesco Frangillo | Friday 25th March 2022 | Non Contract | |
| New Mills | Jake Brooks | Wednesday 30th March 2022 | Non Contract | |
| New Mills | Alexander Capraro | Wednesday 30th March 2022 | Non Contract | |
| New Mills | Alexander Duncan | Wednesday 30th March 2022 | Non Contract | |
| New Mills | Jordan Latham | Wednesday 30th March 2022 | Non Contract | |
| New Mills | Nathan Lees | Thursday 31st March 2022 | Non Contract | |
| New Mills | Harvey Smith | Thursday 31st March 2022 | Non Contract | |
| New Mills | Aiden Theyer | Wednesday 30th March 2022 | Non Contract | |
| New Mills | Harry Wyatt | Wednesday 30th March 2022 | Non Contract | |
| Padiham | Mateusz Kardacz | Friday 25th March 2022 | Temporary | |
| Padiham | Mateusz Kardacz | Friday 25th March 2022 | Work Experience | |
| Pilkington | Robert Ablewhite | Tuesday 29th March 2022 | Non Contract | |
| Pilkington | Rhyce Merrifield | Saturday 26th March 2022 | Non Contract | |
| Rocester | Ky-mani Hunter | Friday 25th March 2022 | Work Experience | |
| Runcorn Town | Ashley Ruane | Friday 25th March 2022 | Non Contract | |
| Sandbach United | Michael Dixon | Thursday 31st March 2022 | Non Contract | |
| Squires Gate | Harrison Kay | Friday 25th March 2022 | Non Contract | |
| St Helens Town | Shaun Kelly | Tuesday 29th March 2022 | Non Contract | |
| Steeton | Jake Townsend | Friday 25th March 2022 | Non Contract | |
| Stockport Town | Lucas Berry | Tuesday 29th March 2022 | Work Experience | |
| Stockport Town | Ben Finley | Tuesday 29th March 2022 | Work Experience | |
| Vauxhall Motors | Callum Hill | Thursday 31st March 2022 | Non Contract | |
| Vauxhall Motors | Toby Jones | Thursday 31st March 2022 | Non Contract | |
| Vauxhall Motors | Thomas Porschke | Wednesday 30th March 2022 | Non Contract | |
| Vauxhall Motors | Joel Robinson | Thursday 31st March 2022 | Non Contract |
| Club | Player Name | Date De-Registered | Reg Type | Role |
| AFC Darwen | Louis Hood | Friday 25th March 2022 | Work Experience | |
| AFC Darwen | Jake Townsend | Saturday 26th March 2022 | Non Contract | |
| Alsager Town | Tom Heyes | Saturday 26th March 2022 | Non Contract | |
| Avro | Osebi Abadaki | Saturday 26th March 2022 | Non Contract | |
| Avro | Jordan Latham | Wednesday 30th March 2022 | Non Contract | |
| Cheadle Heath Nomads | Harrison Cunningham | Saturday 26th March 2022 | Non Contract | |
| Litherland REMYCA | Oscar Billington | Friday 1st April 2022 | Non Contract | |
| Lower Breck | Ricky Ager | Tuesday 29th March 2022 | Non Contract | |
| New Mills | Samuel Amankwaa | Saturday 26th March 2022 | Non Contract | |
| Rocester | Ethan Stanton | Saturday 26th March 2022 | Non Contract | |
| St Helens Town | Rhyce Merrifield | Monday 28th March 2022 | Non Contract | |
| Vauxhall Motors | Michael Dixon | Friday 1st April 2022 | Non Contract | |
| Vauxhall Motors | Ashley Ruane | Saturday 26th March 2022 | Non Contract | |
| Wythenshawe Amateurs | Francesco Frangillo | Friday 25th March 2022 | Non Contract |
