| Wednesday 12th November 2025 | The Edward Case Cup 1st Round North | ||
| 19:45 |  Nelson v MSB Woolton  | Jericho Lane | |
| Played at MSB Woolton | |||
| Saturday 15th November 2025 | The Edward Case Cup 2nd Round North | ||
| 15:00 |  Ashton Town v Darwen FC  | The Bartons Group Stadium | |
| 15:00 |  Maghull v Bacup Borough  | DT Hughes Community Stadium | |
| 15:00 |  Maine Road v AFC Blackpool  | Brantingham Road | |
| Saturday 15th November 2025 | The Edward Case Cup 2nd Round South | ||
| 15:00 |  Barnton v Ashville  | The Creative Hut Stadium | |
| 15:00 |  Runcorn Town v Stafford Town  | Viridor Community Stadium | |
| 15:00 |  Sandbach United v Cheadle Heath Nomads  | Sandbach Community Football Centre | |
| 15:00 |  Telford Town v Stockport Georgians  | DRM Aggregate Arena | |
| To Be Confirmed | The Edward Case Cup 1st Round North | ||
| 15:00 |  Ashton Town v Steeton or Fulwood Amateurs | The Bartons Group Stadium | |
| 15:00 | Nelson v MSB Woolton or Garstang | Little Wembley | |
| Wednesday 12th November 2025 The Edward Case Cup 1st Round North |
|
| Nelson v MSB Woolton (19:45) | |
| Played at MSB Woolton | |
| Saturday 15th November 2025 The Edward Case Cup 2nd Round North |
| Ashton Town v Darwen FC (15:00) |
| Maghull v Bacup Borough (15:00) |
| Maine Road v AFC Blackpool (15:00) |
| Saturday 15th November 2025 The Edward Case Cup 2nd Round South |
| Barnton v Ashville (15:00) |
| Runcorn Town v Stafford Town (15:00) |
| Sandbach United v Cheadle Heath Nomads (15:00) |
| Telford Town v Stockport Georgians (15:00) |
| TBC The Edward Case Cup 1st Round North |
| Ashton Town v Steeton or Fulwood Amateurs (15:00) |
| Nelson v MSB Woolton or Garstang (15:00) |
| TBC The Edward Case Cup 1st Round South |
| Foley Meir or Allscott Heath v Stockport Georgians (15:00) |
| Shawbury United or Wolverhampton Sporting Community v Barnton (15:00) |
| Telford Town or Haughmond v Eccleshall (15:00) |
