| Sat 4th Dec 2021 Premier Division |
|
| AFC Liverpool 4-2 Padiham | |
| Avro 5-3 Litherland REMYCA | |
| Burscough 5-1 Wythenshawe Town | |
| Longridge Town P-P Ashton Athletic | |
| Lower Breck 3-1 Runcorn Town | |
| Macclesfield 2-0 Barnoldswick Town | |
| Northwich Victoria 0-2 Charnock Richard | |
| Prestwich Heys P-P Vauxhall Motors | |
| Squires Gate 0-1 Congleton Town | |
| Winsford United P-P Skelmersdale United |
| Sat 4th Dec 2021 First Division North |
|
| AFC Darwen 2-3 St Helens Town | |
| Ashton Town P-P Bury AFC | |
| Campion 2-5 Steeton | |
| Chadderton P-P Bacup Borough | |
| Cleator Moor Celtic 3-0 Ilkley Town | |
| Daisy Hill P-P AFC Blackpool | |
| Golcar United P-P Holker Old Boys | |
| Nelson P-P Atherton LR | |
| Pilkington 2-2 South Liverpool |
| Sat 4th Dec 2021 First Division South |
|
| Abbey Hulton United 1-2 Stockport Town | |
| Cammell Laird 1907 1-1 Barnton | |
| Cheadle Town 1-1 Brocton | |
| Eccleshall 1-1 Rocester | |
| FC Isle of Man 4-1 Alsager Town | |
| Maine Road 0-4 Abbey Hey | |
| Sandbach United 1-1 West Didsbury & Chorlton | |
| St Martins 2-11 New Mills | |
| Stafford Town 3-3 Cheadle Heath Nomads | |
| Wythenshawe Amateurs A-A Ellesmere Rangers |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Tue 7th Dec 2021 Manchester Premier Cup Quarter Finals |
| Bury AFC v Trafford |
| Tue 7th Dec 2021 Staffordshire Senior Cup 2nd Round |
| Kidsgrove Athletic v Rocester |
| Played at Rocester |
| Tue 7th Dec 2021 West Riding County Cup 2nd Round |
| Harrogate Railway Athletic v Steeton |
| Tue 7th Dec 2021 Premier Division |
| Irlam v Prestwich Heys |
| Tue 7th Dec 2021 Cheshire Senior Cup 2nd Round |
| Macclesfield v Stockport County |
| Vauxhall Motors v 1874 Northwich |
| Fri 10th Dec 2021 Premier Division |
| Runcorn Town v Avro |
| Sat 11th Dec 2021 The Buildbase FA Vase 3rd Round |
| Abbey Hey v Bury AFC |
| Highgate United v Congleton Town |
| Loughborough University v Sandbach United |
| Prestwich Heys v Harborough Town |
| Wythenshawe Town v Billingham Synthonia |
| Sat 11th Dec 2021 Premier Division |
| Ashton Athletic v Northwich Victoria |
| Litherland REMYCA v Barnoldswick Town |
| Longridge Town v Lower Breck |
| Macclesfield v Squires Gate |
| Skelmersdale United v Padiham |
| Winsford United v Vauxhall Motors |
| Sat 11th Dec 2021 First Division North |
| Atherton LR v Golcar United |
| Bacup Borough v Garstang |
| Holker Old Boys v Cleator Moor Celtic |
| Ilkley Town v Ashton Town |
| South Liverpool v Daisy Hill |
| St Helens Town v Campion |
| Steeton v AFC Darwen |
| Sat 11th Dec 2021 First Division South |
| Rocester v FC Isle of Man (13:45) |
| Alsager Town v Ellesmere Rangers |
| Barnton v Abbey Hulton United |
| Brocton v Eccleshall |
| Cammell Laird 1907 v Cheadle Town |
| Cheadle Heath Nomads v Wythenshawe Amateurs |
| St Martins v Stockport Town |
| West Didsbury & Chorlton v Stafford Town |
| Sun 12th Dec 2021 The Buildbase FA Vase 3rd Round |
| AFC Liverpool v Pilkington (14:00) |
| Premier Division | P | GD | Pts | |
| 1 | Macclesfield | 22 | 21 | 50 |
| 2 | Skelmersdale United | 23 | 28 | 48 |
| 3 | Charnock Richard | 23 | 21 | 42 |
| 4 | Wythenshawe Town | 23 | 18 | 41 |
| 5 | Burscough | 23 | 15 | 39 |
| 6 | Lower Breck | 23 | 10 | 38 |
| 7 | Avro | 22 | 10 | 38 |
| 8 | Congleton Town | 23 | 9 | 35 |
| 9 | Northwich Victoria | 23 | 6 | 34 |
| 10 | Irlam | 22 | -3 | 32 |
| 11 | Barnoldswick Town | 23 | 1 | 31 |
| 12 | Winsford United | 23 | -7 | 29 |
| 13 | Longridge Town | 21 | -2 | 28 |
| 14 | AFC Liverpool | 22 | -5 | 27 |
| 15 | Squires Gate | 23 | -6 | 26 |
| 16 | Prestwich Heys | 22 | -14 | 25 |
| 17 | Vauxhall Motors | 22 | -18 | 25 |
| 18 | Padiham | 24 | -10 | 24 |
| 19 | Ashton Athletic | 22 | -18 | 23 |
| 20 | Runcorn Town | 24 | -16 | 20 |
| 21 | Litherland REMYCA | 23 | -40 | 10 |
| First Division North | P | GD | Pts | |
| 1 | Holker Old Boys | 20 | 21 | 46 |
| 2 | Bury AFC | 19 | 36 | 45 |
| 3 | Golcar United | 20 | 19 | 45 |
| 4 | Pilkington | 20 | 9 | 38 |
| 5 | AFC Blackpool | 20 | 12 | 34 |
| 6 | Bacup Borough | 19 | 19 | 32 |
| 7 | Nelson | 21 | 4 | 31 |
| 8 | Garstang | 21 | 6 | 28 |
| 9 | Chadderton | 19 | -4 | 28 |
| 10 | Campion | 22 | 6 | 27 |
| 11 | Steeton | 21 | -3 | 24 |
| 12 | South Liverpool | 19 | -8 | 24 |
| 13 | Cleator Moor Celtic * | 21 | -1 | 23 |
| 14 | Daisy Hill | 19 | -5 | 23 |
| 15 | Ashton Town | 20 | -14 | 22 |
| 16 | Atherton LR | 20 | -17 | 21 |
| 17 | AFC Darwen | 21 | -19 | 18 |
| 18 | Ilkley Town | 20 | -9 | 17 |
| 19 | St Helens Town | 22 | -52 | 10 |
| First Division South | P | GD | Pts | |
| 1 | West Didsbury & Chorlton | 21 | 46 | 55 |
| 2 | New Mills | 21 | 43 | 51 |
| 3 | Abbey Hey | 22 | 40 | 50 |
| 4 | FC Isle of Man | 21 | 38 | 44 |
| 5 | Wythenshawe Amateurs | 21 | 23 | 42 |
| 6 | Cheadle Town | 23 | 22 | 39 |
| 7 | Sandbach United | 22 | 12 | 35 |
| 8 | Stafford Town | 22 | -3 | 32 |
| 9 | Cheadle Heath Nomads | 22 | 0 | 31 |
| 10 | Maine Road | 22 | 12 | 29 |
| 11 | Stockport Town | 22 | 9 | 29 |
| 12 | Ellesmere Rangers | 21 | 3 | 29 |
| 13 | Abbey Hulton United | 22 | -11 | 26 |
| 14 | Cammell Laird 1907 | 21 | -18 | 25 |
| 15 | Barnton | 22 | -15 | 24 |
| 16 | Alsager Town | 22 | -11 | 23 |
| 17 | Brocton | 21 | -28 | 21 |
| 18 | Eccleshall | 22 | -29 | 17 |
| 19 | Rocester | 22 | -26 | 14 |
| 20 | St Martins | 22 | -107 | 2 |
Tables correct as at Sat 4th Dec 2021
