| Sat 25th Sep 2021 The Buildbase FA Vase 2nd Qual Rnd |
| Abbey Hey v Hall Road Rgrs |
| Avro v FC Isle of Man |
| Bacup Borough v Wythenshawe Town |
| Barnoldswick Town v Heaton Stan |
| Burscough v Irlam |
| Cleator Moor v Harrogate RA |
| Emley AFC v Chadderton |
| Garforth Town v Garstang |
| Golcar United v Wythenshawe Am |
| Goole v Maine Road |
| Grimsby Borough v Cheadle Heath |
| Lower Breck v Swallownest |
| Maltby Main v Bury AFC |
| New Mills v AFC Liverpool |
| Prestwich Heys v Brigg Town |
| Rossington Mn v Skelmersdale Utd |
| Runcorn Town v Pilkington |
| Sandbach United v Dudley Town |
| South Liverpool v Dronfield Town |
| Stafford Town v Studley |
| Thackley v Holker OB |
| West Didsbury v Parkgate |
| Winsford United v Gresley Rovers |
| Wolvhmpton Cas v Ellesmere Rngrs |
| Sat 25th Sep 2021 Premier Division |
| Charnock Richard v Padiham |
| Longridge Town v Vauxhall Mtrs |
| Squires Gate v Ashton Athletic |
| Sat 25th Sep 2021 First Division North |
| AFC Blackpool v Ilkley Town |
| Ashton Town v AFC Darwen |
| Campion v St Helens Town |
| Sat 25th Sep 2021 First Division South |
| Barnton v Brocton |
| Cammell Laird v Rocester |
| Stockport Town v Abbey Hulton Utd |
| Premier Division | P | GD | Pts | |
| 1 | Macclesfield | 10 | 9 | 23 |
| 2 | Skelmersdale United | 9 | 13 | 19 |
| 3 | Lower Breck | 11 | 2 | 19 |
| 4 | Wythenshawe Town | 10 | 7 | 18 |
| 5 | Vauxhall Motors | 11 | -2 | 18 |
| 6 | Congleton Town | 11 | 7 | 17 |
| 7 | Northwich Victoria | 10 | 6 | 17 |
| 8 | Longridge Town | 11 | 3 | 17 |
| 9 | Avro | 9 | 5 | 16 |
| 10 | Irlam | 10 | 2 | 16 |
| 11 | Prestwich Heys | 11 | -6 | 15 |
| 12 | Charnock Richard | 9 | 10 | 14 |
| 13 | Barnoldswick Town | 9 | 5 | 14 |
| 14 | Burscough | 10 | 2 | 14 |
| 15 | Winsford United | 11 | -8 | 14 |
| 16 | AFC Liverpool | 10 | -5 | 12 |
| 17 | Runcorn Town | 10 | -3 | 10 |
| 18 | Squires Gate | 8 | 0 | 9 |
| 19 | Padiham | 10 | -5 | 8 |
| 20 | Ashton Athletic | 11 | -16 | 8 |
| 21 | Litherland REMYCA | 11 | -26 | 0 |
| First Division North | P | GD | Pts | |
| 1 | Golcar United | 10 | 13 | 24 |
| 2 | Bury AFC | 10 | 12 | 24 |
| 3 | Pilkington | 10 | 7 | 22 |
| 4 | Holker Old Boys | 10 | 4 | 22 |
| 5 | AFC Blackpool | 11 | 9 | 21 |
| 6 | Bacup Borough | 11 | 6 | 16 |
| 7 | South Liverpool | 11 | 3 | 16 |
| 8 | Nelson | 11 | 2 | 16 |
| 9 | Chadderton | 10 | 2 | 15 |
| 10 | Ashton Town | 10 | 2 | 14 |
| 11 | Garstang | 10 | 2 | 13 |
| 12 | Daisy Hill | 11 | 0 | 11 |
| 13 | Atherton LR | 10 | -3 | 11 |
| 14 | Steeton | 10 | -5 | 9 |
| 15 | Ilkley Town | 10 | -6 | 9 |
| 16 | AFC Darwen | 10 | -13 | 9 |
| 17 | Campion | 10 | -2 | 8 |
| 18 | St Helens Town | 11 | -31 | 3 |
| 19 | Cleator Moor Celtic * | 8 | -2 | 2 |
| First Division South | P | GD | Pts | |
| 1 | West Didsbury & Chorlton | 11 | 25 | 29 |
| 2 | New Mills | 10 | 21 | 28 |
| 3 | Wythenshawe Amateurs | 11 | 20 | 26 |
| 4 | Abbey Hey | 11 | 17 | 25 |
| 5 | Sandbach United | 11 | 18 | 23 |
| 6 | Cheadle Town | 10 | 12 | 21 |
| 7 | Ellesmere Rangers | 11 | 11 | 20 |
| 8 | Abbey Hulton United | 11 | -3 | 16 |
| 9 | Cheadle Heath Nomads | 11 | -2 | 15 |
| 10 | Stafford Town | 11 | -5 | 15 |
| 11 | Brocton | 11 | -15 | 13 |
| 12 | FC Isle of Man | 8 | 5 | 12 |
| 13 | Barnton | 10 | -7 | 12 |
| 14 | Maine Road | 11 | -6 | 10 |
| 15 | Cammell Laird 1907 | 11 | -10 | 10 |
| 16 | Alsager Town | 11 | -14 | 10 |
| 17 | Stockport Town | 11 | -3 | 7 |
| 18 | Eccleshall | 11 | -13 | 7 |
| 19 | Rocester | 11 | -15 | 7 |
| 20 | St Martins | 11 | -36 | 2 |
Tables correct as at Wednesday 22nd September 2021
