| Saturday 14th May 2022 The Macron Cup Final |
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| Charnock Richard | 5-0 | Cammell Laird 1907 |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Saturday 21st May 2022 The First Division Cup Final |
| FC Isle of Man v Cammell Laird 1907 |
| Premier Division | P | GD | Pts | |
| 1 | Macclesfield (C) | 40 | 56 | 94 |
| 2 | Skelmersdale United (P) | 40 | 43 | 79 |
| 3 | Wythenshawe Town | 40 | 40 | 78 |
| 4 | Charnock Richard | 40 | 37 | 78 |
| 5 | Northwich Victoria | 40 | 10 | 63 |
| 6 | Avro | 40 | 6 | 62 |
| 7 | Burscough | 40 | 7 | 59 |
| 8 | Vauxhall Motors | 40 | -14 | 59 |
| 9 | Congleton Town | 40 | 13 | 58 |
| 10 | Irlam | 40 | -6 | 57 |
| 11 | Winsford United | 40 | 0 | 54 |
| 12 | Longridge Town | 40 | -9 | 52 |
| 13 | Padiham | 40 | -8 | 50 |
| 14 | AFC Liverpool | 40 | 0 | 49 |
| 15 | Barnoldswick Town | 40 | -9 | 47 |
| 16 | Prestwich Heys | 40 | -20 | 45 |
| 17 | Squires Gate | 40 | -13 | 44 |
| 18 | Ashton Athletic | 40 | -32 | 43 |
| 19 | Lower Breck | 40 | -26 | 42 |
| 20 | Litherland REMYCA (R) | 40 | -35 | 33 |
| 21 | Runcorn Town (R) | 40 | -40 | 27 |
| First Division North | P | GD | Pts | |
| 1 | Bury AFC (C) | 36 | 60 | 89 |
| 2 | Holker Old Boys | 36 | 39 | 78 |
| 3 | Golcar United (P) | 36 | 16 | 66 |
| 4 | AFC Blackpool | 36 | 19 | 58 |
| 5 | Nelson | 36 | 13 | 58 |
| 6 | Pilkington | 36 | -2 | 56 |
| 7 | Bacup Borough | 36 | 24 | 54 |
| 8 | Daisy Hill | 36 | 3 | 51 |
| 9 | Cleator Moor Celtic * | 36 | 9 | 49 |
| 10 | Garstang | 36 | 6 | 49 |
| 11 | Chadderton | 36 | -7 | 49 |
| 12 | Steeton | 36 | -11 | 47 |
| 13 | South Liverpool | 36 | -10 | 45 |
| 14 | Ashton Town | 36 | -19 | 41 |
| 15 | Ilkley Town | 36 | 0 | 40 |
| 16 | Campion | 36 | -6 | 40 |
| 17 | AFC Darwen (R) | 36 | -24 | 39 |
| 18 | Atherton LR (R) | 36 | -27 | 37 |
| 19 | St Helens Town (R) | 36 | -83 | 16 |
| First Division South | P | GD | Pts | |
| 1 | West Didsbury & Chorlton (C) | 38 | 85 | 91 |
| 2 | FC Isle of Man (P) | 38 | 69 | 86 |
| 3 | New Mills | 38 | 68 | 84 |
| 4 | Abbey Hey | 38 | 63 | 84 |
| 5 | Wythenshawe Amateurs | 38 | 56 | 82 |
| 6 | Maine Road | 38 | 36 | 62 |
| 7 | Cheadle Town | 38 | 32 | 60 |
| 8 | Sandbach United | 38 | 24 | 60 |
| 9 | Cheadle Heath Nomads | 38 | 2 | 50 |
| 10 | Brocton | 38 | -13 | 50 |
| 11 | Stockport Town | 38 | 20 | 48 |
| 12 | Stafford Town | 38 | -20 | 47 |
| 13 | Barnton | 38 | -17 | 43 |
| 14 | Cammell Laird 1907 | 38 | -30 | 43 |
| 15 | Ellesmere Rangers | 38 | -15 | 42 |
| 16 | Abbey Hulton United | 38 | -18 | 42 |
| 17 | Eccleshall | 38 | -31 | 39 |
| 18 | Alsager Town (R) | 38 | -42 | 29 |
| 19 | Rocester (R) | 38 | -46 | 29 |
| 20 | St Martins (R) | 38 | -223 | 2 |
Tables correct as at Sat 2nd Apr 2022
