| Wed 28th Jul 2021 Pre-Season Friendly |
|
| Longridge Town v Clitheroe | |
| Sandbach United v South Liverpool |
| Mon 26th Jul 2021 Pre-Season Friendly |
|
| Liversedge P-P Steeton | |
| Winsford United v Mossley AFC |
| Sat 24th Jul 2021 The Macron Cup Final |
|
| Runcorn Town 3-6 1874 Northwich |
| Sat 24th Jul 2021 Pre-Season Friendly |
|
| Abbey Hulton United 3-1 Leek CSOB | |
| AFC Blackpool 2-3 West Allotment Celtic | |
| AFC Darwen 5-2 Turton | |
| AFC Knowsley 4-4 St Helens Town | |
| Ashton Town 2-2 Litherland REMYCA | |
| Avro 1-1 Oldham Athletic XI | |
| Blacon Youth Club v South Liverpool | |
| Bootle 0-2 Lower Breck | |
| Cammell Laird 1907 1-1 Marine | |
| Chadderton 0-3 Trafford | |
| Chadderton 0-3 Trafford | |
| Cheadle Heath Nomads 0-3 Mossley AFC | |
| Colne 5-0 Barnoldswick Town | |
| Congleton Town 3-1 Crewe Alexandra XI | |
| Ellesmere Rangers 0-1 Newtown | |
| Knutsford 1-2 Cheadle Town | |
| Longridge Town 1-7 Bamber Bridge | |
| New Mills 2-1 Wythenshawe Town | |
| Otley Town 0-4 Ilkley Town | |
| Ramsbottom United 2-0 Bury AFC | |
| Rocester 0-2 Burscough Richmond | |
| Skelmersdale United 0-1 Accrington Stanley | |
| Squires Gate 2-1 Golcar United | |
| St Martins v St Martins | |
| Steeton 1-3 Maine Road | |
| Vauxhall Motors 1-2 Abbey Hey | |
| Witton Albion 4-1 Northwich Victoria |
| Sat 31st Jul 2021 Premier Division |
| Ashton Athletic v Wythenshawe Town |
| Avro v Padiham |
| Charnock Rich v Winsford United |
| Irlam v Lith REMYCA |
| Longridge Town v Congleton Town |
| Macclesfield v Burscough |
| Prestwich Heys v Northwich Vics |
| Runcorn Town v Barnoldswick Tn |
| Squires Gate v Lower Breck |
| Vauxhall Mtrs v AFC Liverpool |
| Sat 31st Jul 2021 First Division North |
| AFC Darwen v South Liverpool |
| Ashton Town v AFC Blackpool |
| Bacup Borough v Cleator Moor |
| Daisy Hill v Chadderton |
| Garstang v Campion |
| Holker OB v Golcar United |
| Ilkley Town 2-4 Bury AFC |
| Nelson v Pilkington |
| St Helens Town v Atherton LR |
| Sat 31st Jul 2021 First Division South |
| Abbey Hey v Stockport Town |
| Alsager Town v West Didsbury |
| Barnton v Wythenshawe Am |
| Cammell Laird v Cheadle Heath |
| Cheadle Town v New Mills |
| Maine Road 1-1 FC Isle of Man (14:00) |
| Rocester v Eccleshall |
| Sandbach v Brocton |
| St Martins v Abbey Hulton |
| Stafford Town v Ellesmere Rngrs |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Mon 2nd Aug 2021 Lancashire Challenge Trophy Final |
| Lancaster City v Prestwich Heys (19:30) |
| Played at The County Ground |
| Mon 2nd Aug 2021 First Division South |
| Maine Road v Wythenshawe Amateurs |
| Stockport Town v West Didsbury & Chorlton |
| Tue 3rd Aug 2021 Premier Division |
| Barnoldswick Town v Squires Gate |
| Burscough v Ashton Athletic |
| Irlam v Congleton Town |
| Winsford United v Macclesfield |
| Wythenshawe Town v Padiham |
| Skelmersdale United v Longridge Town (20:00) |
| Tue 3rd Aug 2021 First Division North |
| AFC Blackpool v Holker Old Boys |
| Atherton LR v Bury AFC |
| Campion v Golcar United |
| Nelson v Steeton |
| Bacup Borough v Ilkley Town (20:00) |
| Tue 3rd Aug 2021 First Division South |
| Abbey Hulton United v Rocester |
| Cammell Laird 1907 v Ellesmere Rangers |
| Eccleshall v Brocton |
| New Mills v Cheadle Heath Nomads |
| Sandbach United v St Martins |
| Stafford Town v Alsager Town |
| Wed 4th Aug 2021 Premier Division |
| Litherland REMYCA v Runcorn Town |
| Northwich Victoria v Avro |
| Wed 4th Aug 2021 First Division North |
| AFC Darwen v Chadderton |
| Garstang v St Helens Town |
| Pilkington v Daisy Hill |
| South Liverpool v Ashton Town |
| Wed 4th Aug 2021 First Division South |
| Barnton P-P FC Isle of Man |
| (Postponed due to Isle of Man isolation issues) |
| Cheadle Town v Abbey Hey |
| Sat 7th Aug 2021 The Emirates F.A Cup Extra Preliminary Round |
| Ashton Athletic v Squires Gate |
| Athersley Recreation v Campion |
| Barnoldswick Town v Runcorn Town |
| Irlam v Albion Sports |
| Longridge Town v Northwich Victoria |
| Lower Breck v Penistone Church |
| Macclesfield v Burscough |
| Padiham v AFC Liverpool |
| Prestwich Heys v Litherland REMYCA |
| Thackley v Wythenshawe Town |
| Vauxhall Motors v Skelmersdale United |
| West Didsbury & Chorlton v Avro |
| Winsford United v Charnock Richard |
| Sat 7th Aug 2021 First Division North |
| AFC Blackpool v Cleator Moor Celtic |
| Ashton Town v Ilkley Town |
| Bury AFC v Bacup Borough |
| Chadderton v Atherton LR |
| Daisy Hill v Garstang |
| Golcar United v Nelson |
| Holker Old Boys v AFC Darwen |
| St Helens Town v Pilkington |
| Steeton v South Liverpool |
| Sat 7th Aug 2021 First Division South |
| Wythenshawe Amateurs v FC Isle of Man (14:00) |
| Abbey Hulton United v Barnton |
| Alsager Town v Maine Road |
| Brocton v Cammell Laird 1907 |
| Cheadle Heath Nomads v Abbey Hey |
| Eccleshall v Stockport Town |
| Ellesmere Rangers v Sandbach United |
| Rocester v Cheadle Town |
| St Martins v Stafford Town |
| Sun 8th Aug 2021 The Emirates F.A Cup Extra Preliminary Round |
| Emley AFC v Congleton Town (13:30) |
| Premier Division | P | GD | Pts | |
| 1 | AFC Liverpool | 0 | 0 | 0 |
| 2 | Ashton Athletic | 0 | 0 | 0 |
| 3 | Avro | 0 | 0 | 0 |
| 4 | Barnoldswick Town | 0 | 0 | 0 |
| 5 | Burscough | 0 | 0 | 0 |
| 6 | Charnock Richard | 0 | 0 | 0 |
| 7 | Congleton Town | 0 | 0 | 0 |
| 8 | Irlam | 0 | 0 | 0 |
| 9 | Litherland REMYCA | 0 | 0 | 0 |
| 10 | Longridge Town | 0 | 0 | 0 |
| 11 | Lower Breck | 0 | 0 | 0 |
| 12 | Macclesfield | 0 | 0 | 0 |
| 13 | Northwich Victoria | 0 | 0 | 0 |
| 14 | Padiham | 0 | 0 | 0 |
| 15 | Prestwich Heys | 0 | 0 | 0 |
| 16 | Runcorn Town | 0 | 0 | 0 |
| 17 | Skelmersdale United | 0 | 0 | 0 |
| 18 | Squires Gate | 0 | 0 | 0 |
| 19 | Vauxhall Motors | 0 | 0 | 0 |
| 20 | Winsford United | 0 | 0 | 0 |
| 21 | Wythenshawe Town | 0 | 0 | 0 |
| First Division North | P | GD | Pts | |
| 1 | AFC Blackpool | 0 | 0 | 0 |
| 2 | AFC Darwen | 0 | 0 | 0 |
| 3 | Ashton Town | 0 | 0 | 0 |
| 4 | Atherton LR | 0 | 0 | 0 |
| 5 | Bacup Borough | 0 | 0 | 0 |
| 6 | Bury AFC | 0 | 0 | 0 |
| 7 | Campion | 0 | 0 | 0 |
| 8 | Chadderton | 0 | 0 | 0 |
| 9 | Cleator Moor Celtic | 0 | 0 | 0 |
| 10 | Daisy Hill | 0 | 0 | 0 |
| 11 | Garstang | 0 | 0 | 0 |
| 12 | Golcar United | 0 | 0 | 0 |
| 13 | Holker Old Boys | 0 | 0 | 0 |
| 14 | Ilkley Town | 0 | 0 | 0 |
| 15 | Nelson | 0 | 0 | 0 |
| 16 | Pilkington | 0 | 0 | 0 |
| 17 | South Liverpool | 0 | 0 | 0 |
| 18 | St Helens Town | 0 | 0 | 0 |
| 19 | Steeton | 0 | 0 | 0 |
| First Division South | P | GD | Pts | |
| 1 | Abbey Hey | 0 | 0 | 0 |
| 2 | Abbey Hulton United | 0 | 0 | 0 |
| 3 | Alsager Town | 0 | 0 | 0 |
| 4 | Barnton | 0 | 0 | 0 |
| 5 | Brocton | 0 | 0 | 0 |
| 6 | Cammell Laird 1907 | 0 | 0 | 0 |
| 7 | Cheadle Heath Nomads | 0 | 0 | 0 |
| 8 | Cheadle Town | 0 | 0 | 0 |
| 9 | Eccleshall | 0 | 0 | 0 |
| 10 | Ellesmere Rangers | 0 | 0 | 0 |
| 11 | FC Isle of Man | 0 | 0 | 0 |
| 12 | Maine Road | 0 | 0 | 0 |
| 13 | New Mills | 0 | 0 | 0 |
| 14 | Rocester | 0 | 0 | 0 |
| 15 | Sandbach United | 0 | 0 | 0 |
| 16 | St Martins | 0 | 0 | 0 |
| 17 | Stafford Town | 0 | 0 | 0 |
| 18 | Stockport Town | 0 | 0 | 0 |
| 19 | West Didsbury & Chorlton | 0 | 0 | 0 |
| 20 | Wythenshawe Amateurs | 0 | 0 | 0 |
Tables correct as at Fri 30th Jul 2021
