| Wed 26th Jan 2022 First Division North |
|
| AFC Darwen 2-3 South Liverpool |
| Tue 25th Jan 2022 Premier Division |
|
| Ashton Athletic 1-1 Northwich Victoria | |
| Congleton Town 2-3 Charnock Richard | |
| Runcorn Town 1-1 Prestwich Heys | |
| Vauxhall Motors 2-1 Lower Breck |
| Tue 25th Jan 2022 First Division North |
|
| AFC Blackpool 2-3 Atherton LR | |
| Campion 1-2 Bury AFC |
| Mon 24th Jan 2022 First Division South |
|
| Maine Road 4-0 Alsager Town |
| Sat 22nd Jan 2022 Premier Division |
|
| Barnoldswick Town 2-2 AFC Liverpool | |
| Charnock Richard 1-1 Macclesfield | |
| Irlam 2-1 Burscough | |
| Lower Breck 0-2 Avro | |
| Northwich Victoria 1-0 Litherland REMYCA | |
| Prestwich Heys 1-1 Wythenshawe Town | |
| Runcorn Town 1-1 Squires Gate | |
| Skelmersdale United 3-2 Congleton Town | |
| Vauxhall Motors 0-2 Ashton Athletic |
| Sat 22nd Jan 2022 First Division North |
|
| Ashton Town 1-2 Garstang | |
| Bacup Borough 3-1 Campion | |
| Golcar United 4-0 Daisy Hill | |
| Holker Old Boys 3-0 St Helens Town | |
| Ilkley Town 1-2 Chadderton | |
| Nelson 3-0 AFC Blackpool | |
| Pilkington A-A Cleator Moor Celtic | |
| South Liverpool 0-2 Bury AFC | |
| Steeton 2-2 Atherton LR |
| Sat 22nd Jan 2022 First Division South |
|
| Abbey Hey 2-2 Sandbach United | |
| Barnton 4-1 Rocester | |
| Brocton 2-1 Ellesmere Rangers | |
| Cammell Laird 1907 2-1 Stafford Town | |
| Cheadle Heath Nomads 3-1 Alsager Town | |
| Eccleshall 6-0 St Martins | |
| FC Isle of Man 5-2 Cheadle Town | |
| Stockport Town 2-2 New Mills | |
| West Didsbury & Chorlton 4-1 Abbey Hulton United | |
| Wythenshawe Amateurs 2-1 Maine Road |
| Fri 28th Jan 2022 Premier Division |
| Litherland REMY v Irlam |
| (Played at Bootle) |
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Sat 29th Jan 2022 Premier Division |
| AFC Liverpool v Vauxhall Motors |
| Ashton Athletic v Congleton Town |
| Avro v Burscough |
| Charnock Richard v Lower Breck |
| Longridge Town v Winsford United |
| Macclesfield v Skelmersdale United |
| Padiham v Northwich Victoria |
| Squires Gate v Prestwich Heys |
| Wythenshawe Town v Runcorn Town |
| Sat 29th Jan 2022 First Division North |
| AFC Blackpool v St Helens Town |
| Ashton Town v South Liverpool |
| Bacup Borough v Golcar United |
| Bury AFC v Atherton LR |
| Chadderton v AFC Darwen |
| Daisy Hill v Cleator Moor Celtic |
| Garstang v Pilkington |
| Holker Old Boys v Steeton |
| Nelson v Ilkley Town |
| Sat 29th Jan 2022 First Division South |
| Abbey Hey v Eccleshall |
| Abbey Hulton United v Alsager Town |
| Cheadle Heath Nomads v Cammell Laird 1907 |
| Ellesmere Rangers v Cheadle Town |
| Maine Road v Brocton |
| New Mills v West Didsbury & Chorlton |
| Rocester v St Martins |
| Stafford Town v Wythenshawe Amateurs |
| Stockport Town v Sandbach United |
| FC Isle of Man v Barnton (18:30) |
| Premier Division | P | GD | Pts | |
| 1 | Skelmersdale United | 28 | 35 | 60 |
| 2 | Macclesfield | 28 | 21 | 60 |
| 3 | Wythenshawe Town | 30 | 24 | 55 |
| 4 | Charnock Richard | 28 | 27 | 53 |
| 5 | Avro | 28 | 16 | 50 |
| 6 | Burscough | 29 | 11 | 45 |
| 7 | Northwich Victoria | 28 | 14 | 44 |
| 8 | Longridge Town | 28 | 5 | 42 |
| 9 | Congleton Town | 29 | 8 | 41 |
| 10 | Lower Breck | 29 | -7 | 39 |
| 11 | Vauxhall Motors | 28 | -14 | 37 |
| 12 | Irlam | 27 | -7 | 36 |
| 13 | Prestwich Heys | 28 | -9 | 36 |
| 14 | Barnoldswick Town | 28 | -3 | 35 |
| 15 | AFC Liverpool | 26 | 0 | 33 |
| 16 | Winsford United | 26 | -7 | 33 |
| 17 | Squires Gate | 28 | -6 | 31 |
| 18 | Padiham | 29 | -14 | 30 |
| 19 | Ashton Athletic | 29 | -28 | 28 |
| 20 | Runcorn Town | 29 | -23 | 22 |
| 21 | Litherland REMYCA | 27 | -43 | 13 |
| First Division North | P | GD | Pts | |
| 1 | Bury AFC | 26 | 48 | 66 |
| 2 | Golcar United | 26 | 27 | 60 |
| 3 | Holker Old Boys | 25 | 25 | 55 |
| 4 | Bacup Borough | 26 | 25 | 44 |
| 5 | AFC Blackpool | 26 | 9 | 41 |
| 6 | Pilkington | 24 | 1 | 41 |
| 7 | Garstang | 27 | 6 | 39 |
| 8 | Nelson | 26 | 7 | 37 |
| 9 | Chadderton | 25 | -3 | 36 |
| 10 | Daisy Hill | 27 | -10 | 33 |
| 11 | Campion | 27 | 5 | 31 |
| 12 | Steeton | 26 | -2 | 31 |
| 13 | Ashton Town | 26 | -12 | 31 |
| 14 | South Liverpool | 26 | -13 | 31 |
| 15 | Ilkley Town | 26 | -2 | 30 |
| 16 | Atherton LR | 27 | -21 | 28 |
| 17 | Cleator Moor Celtic * | 26 | -4 | 27 |
| 18 | AFC Darwen | 26 | -23 | 22 |
| 19 | St Helens Town | 28 | -63 | 13 |
| First Division South | P | GD | Pts | |
| 1 | West Didsbury & Chorlton | 26 | 54 | 65 |
| 2 | New Mills | 27 | 46 | 60 |
| 3 | FC Isle of Man | 27 | 45 | 57 |
| 4 | Abbey Hey | 27 | 38 | 56 |
| 5 | Wythenshawe Amateurs | 28 | 30 | 54 |
| 6 | Cheadle Town | 28 | 23 | 47 |
| 7 | Sandbach United | 27 | 12 | 43 |
| 8 | Stafford Town | 27 | -1 | 37 |
| 9 | Cammell Laird 1907 | 28 | -15 | 37 |
| 10 | Ellesmere Rangers | 27 | 2 | 36 |
| 11 | Cheadle Heath Nomads | 26 | -2 | 35 |
| 12 | Brocton | 28 | -17 | 35 |
| 13 | Stockport Town | 26 | 14 | 34 |
| 14 | Maine Road | 25 | 15 | 33 |
| 15 | Barnton | 27 | -9 | 33 |
| 16 | Abbey Hulton United | 27 | -13 | 29 |
| 17 | Eccleshall | 27 | -23 | 27 |
| 18 | Alsager Town | 27 | -20 | 24 |
| 19 | Rocester | 27 | -36 | 18 |
| 20 | St Martins | 28 | -143 | 2 |
Tables correct as at Tue 25th Jan 2022
