| Thursday 18th August 2022 Premier Division |
||
| Lower Breck | 2-0 | Burscough |
| Wednesday 17th August 2022 Premier Division |
||
| Bury AFC | 0-2 | Prestwich Heys |
| Litherland REMYCA | 1-3 | Wythenshawe Town |
| Squires Gate | 0-2 | Padiham |
| Tuesday 16th August 2022 Premier Division |
||
| Barnoldswick Town | 0-3 | Avro |
| Charnock Richard | 3-2 | Ashton Athletic |
| Longridge Town | 0-3 | AFC Liverpool |
| Vauxhall Motors | 2-0 | West Didsbury & Chorlton |
| Tuesday 16th August 2022 First Division South |
||
| Brocton | 3-1 | Cheadle Heath Nomads |
| Cammell Laird 1907 | 3-2 | New Mills |
| Cheadle Town | 1-2 | Ellesmere Rangers |
| Wythenshawe Amateurs | 3-1 | Abbey Hulton United |
| Monday 15th August 2022 Premier Division |
||
| Winsford United | 1-1 | Northwich Victoria |
| Monday 15th August 2022 First Division South |
||
| Stockport Town | P-P | Eccleshall |
| Postponed due to management committee approval | ||
| Saturday 13th August 2022 First Division North |
||
| AFC Blackpool | 3-0 | Ashton Town |
| Atherton LR | 1-6 | Pilkington |
| Bacup Borough | 4-3 | Nelson |
| Cleator Moor Celtic | 0-1 | Daisy Hill |
| Darwen FC | 2-1 | Steeton |
| FC St Helens | 0-0 | Ilkley Town |
| Holker Old Boys | 3-0 | Garstang |
| Runcorn Town | 1-2 | Chadderton |
| South Liverpool | 1-3 | Euxton Villa |
| Fri 19th Aug 2022 The Emirates F.A Cup Preliminary Round |
|||
| 19:45 | Northwich Victoria v West Didsbury & Chorlton | ||
Saturday KO 15:00, Midweek KO 19:45 unless stated
| Saturday 20th August 2022 The Emirates F.A Cup Preliminary Round |
| Avro v Albion Sports |
| Bishop Auckland v Kendal Town |
| Congleton Town v Bootle |
| Prestwich Heys v Stocksbridge Park Steels |
| Silsden v Charnock Richard |
| Saturday 20th August 2022 Premier Division |
| Burscough P-P Barnoldswick Town |
| (Postponed due to Skem in FA Cup. Now Sunday. ) |
| Litherland REMYCA v Ashton Athletic |
| Lower Breck v Irlam |
| Squires Gate v Longridge Town |
| Vauxhall Motors v FC Isle of Man |
| Saturday 20th August 2022 First Division North |
| Ashton Town v Atherton LR |
| Chadderton v Pilkington |
| Cleator Moor Celtic v South Liverpool |
| Daisy Hill v Darwen FC |
| Euxton Villa v Runcorn Town |
| FC St Helens v Bacup Borough |
| Garstang v Steeton |
| Ilkley Town v Holker Old Boys |
| Nelson v AFC Blackpool |
| Saturday 20th August 2022 First Division South |
| Abbey Hulton United v Stockport Georgians |
| Alsager Town v Cheadle Heath Nomads |
| Ashville v Maine Road |
| Barnton v Cammell Laird 1907 |
| Cheadle Town v Wythenshawe Amateurs |
| Ellesmere Rangers v Brocton |
| Rocester v New Mills |
| Sandbach United v Foley Meir |
| Stafford Town v Eccleshall |
| Stockport Town v Abbey Hey |
| Sunday 21st August 2022 The Emirates F.A Cup Preliminary Round |
| Bury AFC v Widnes |
| Sunday 21st August 2022 Premier Division |
| Burscough v Barnoldswick Town |
| Premier Division | P | GD | Pts | |
| 1 | Avro | 5 | 11 | 15 |
| 2 | AFC Liverpool | 5 | 11 | 12 |
| 3 | Vauxhall Motors | 4 | 7 | 12 |
| 4 | Prestwich Heys | 4 | 7 | 9 |
| 5 | Wythenshawe Town | 3 | 6 | 9 |
| 6 | Bury AFC | 4 | 2 | 9 |
| 7 | West Didsbury & Chorlton | 5 | 2 | 8 |
| 8 | Charnock Richard | 4 | 0 | 7 |
| 9 | FC Isle of Man | 3 | 1 | 6 |
| 10 | Lower Breck | 4 | 1 | 6 |
| 11 | Barnoldswick Town | 4 | -1 | 6 |
| 12 | Longridge Town | 3 | -1 | 6 |
| 13 | Congleton Town | 4 | 2 | 4 |
| 14 | Northwich Victoria | 3 | 1 | 4 |
| 15 | Padiham | 5 | -5 | 4 |
| 16 | Squires Gate | 5 | -5 | 4 |
| 17 | Burscough | 4 | -8 | 3 |
| 18 | Ashton Athletic | 4 | -6 | 1 |
| 19 | Irlam | 4 | -6 | 1 |
| 20 | Winsford United | 4 | -6 | 1 |
| 21 | Litherland REMYCA | 4 | -6 | 0 |
| 22 | Kendal Town | 3 | -7 | 0 |
| First Division North | P | GD | Pts | |
| 1 | Pilkington | 4 | 15 | 12 |
| 2 | Chadderton | 4 | 5 | 12 |
| 3 | Ilkley Town | 4 | 7 | 10 |
| 4 | Euxton Villa | 3 | 5 | 9 |
| 5 | Garstang | 4 | 3 | 9 |
| 6 | Daisy Hill | 4 | 0 | 9 |
| 7 | AFC Blackpool | 3 | 5 | 7 |
| 8 | Steeton | 4 | 3 | 6 |
| 9 | FC St Helens | 3 | 4 | 5 |
| 10 | Holker Old Boys | 3 | 1 | 3 |
| 11 | Nelson | 3 | -2 | 3 |
| 12 | Bacup Borough | 4 | -3 | 3 |
| 13 | Darwen FC | 3 | -4 | 3 |
| 14 | Runcorn Town | 4 | -8 | 1 |
| 15 | Atherton LR | 4 | -9 | 1 |
| 16 | South Liverpool | 3 | -5 | 0 |
| 17 | Cleator Moor Celtic | 3 | -8 | 0 |
| 18 | Ashton Town | 4 | -9 | 0 |
| First Division South | P | GD | Pts | |
| 1 | Wythenshawe Amateurs | 5 | 11 | 15 |
| 2 | Ellesmere Rangers | 5 | 6 | 13 |
| 3 | Brocton | 5 | 4 | 10 |
| 4 | Stockport Town | 4 | 5 | 9 |
| 5 | Ashville | 4 | 7 | 8 |
| 6 | Sandbach United | 4 | 4 | 7 |
| 7 | Eccleshall | 3 | 3 | 7 |
| 8 | Cheadle Town | 5 | 2 | 7 |
| 9 | Abbey Hey | 4 | 0 | 6 |
| 10 | Abbey Hulton United | 5 | 1 | 4 |
| 11 | Stafford Town | 4 | -1 | 4 |
| 12 | New Mills | 5 | -2 | 4 |
| 13 | Maine Road | 4 | -2 | 4 |
| 14 | Barnton | 4 | -3 | 4 |
| 15 | Alsager Town | 4 | -4 | 4 |
| 16 | Cammell Laird 1907 | 5 | -5 | 4 |
| 17 | Foley Meir | 2 | -5 | 3 |
| 18 | Cheadle Heath Nomads | 4 | -4 | 1 |
| 19 | Stockport Georgians | 3 | -5 | 1 |
| 20 | Rocester | 3 | -12 | 0 |
Tables correct as at Fri 19th Aug 2022
