| Saturday 29th March 2025 | Premier Division | ||
| 15:00 |  Abbey Hey v Padiham  | The Abbey Stadium | |
| 15:00 |  Bury v Squires Gate  | Gigg Lane | |
| 15:00 |  Cheadle Town v Burscough  | The Ground Up Solutions Stadium | |
| 15:00 |  Litherland REMYCA v Colne  | Litherland Sports Park | |
| 15:00 |  Longridge Town v Pilkington  | Longridge Town FC | |
| 15:00 |  Prestwich Heys v Ramsbottom United  | Adie Moran Park | |
| 15:00 |  South Liverpool v Irlam  | Jericho Lane | |
| 15:00 |  Stockport Town v FC St Helens  | Stockport Sports Village | |
| 15:00 |  West Didsbury & Chorlton v Chadderton  | Step Places Stadium | |
| 18:00 |  FC Isle of Man v Lower Breck  | The Bowl | |
| Friday 4th April 2025 | Premier Division | ||
| 19:45 | Chadderton v Pilkington | Vestacare Stadium | |
| Played at Avro | |||
| 20:00 | Lower Breck v Litherland REMYCA | Anfield Sports Community Centre | |
| Saturday 5th April 2025 | Premier Division | ||
| 15:00 |  AFC Liverpool v West Didsbury & Chorlton | The Marine Travel Arena | |
| 15:00 |  Barnoldswick Town v Prestwich Heys | Silentnight Stadium | |
| 15:00 | Burscough v Longridge Town | The Community Ground | |
| 15:00 | Bury v Padiham | Gigg Lane | |
| 15:00 | Colne v Cheadle Town | Haffners Stadium | |
| 15:00 | FC St Helens v South Liverpool | SMS PRO SOCCER PARK | |
| 15:00 | Irlam v Abbey Hey | The Silver St Stadium | |
| 15:00 | Ramsbottom United v Stockport Town | Harry Williams Riverside Stadium | |
| 15:00 | Squires Gate v Glossop North End  | The Brian Addison Stadium | |
| 18:00 | FC Isle of Man v Charnock Richard  | The Bowl | |
| Friday 11th April 2025 | Premier Division | ||
| 20:00 | AFC Liverpool v Colne | The Marine Travel Arena | |
| Saturday 12th April 2025 | Premier Division | ||
| 15:00 | Abbey Hey v FC St Helens | The Abbey Stadium | |
| 15:00 | Chadderton v Ramsbottom United | The Falcon Fire Stadium | |
| 15:00 | Cheadle Town v Bury | The Ground Up Solutions Stadium | |
| 15:00 | Glossop North End v Burscough | The Asgard Engineering Stadium | |
| 15:00 | Lower Breck v Barnoldswick Town | Anfield Sports Community Centre | |
| 15:00 | Padiham v South Liverpool | Ruby Civil Arena | |
| 15:00 | Pilkington v Squires Gate | PSD Stadium | |
| 15:00 | Prestwich Heys v Irlam | Adie Moran Park | |
| 15:00 | Stockport Town v Charnock Richard | Stockport Sports Village | |
| 15:00 | West Didsbury & Chorlton v Longridge Town | Step Places Stadium | |
| 18:00 | FC Isle of Man v Litherland REMYCA | The Bowl | |
| Saturday 19th April 2025 | Premier Division | ||
| 15:00 | Bury v Burscough | Gigg Lane | |
| 15:00 | Chadderton v Litherland REMYCA | The Falcon Fire Stadium | |
| 15:00 | Charnock Richard v Squires Gate | Mossie Park | |
| 15:00 | Cheadle Town v Lower Breck | The Ground Up Solutions Stadium | |
| 15:00 | Colne v Abbey Hey | Haffners Stadium | |
| 15:00 | FC Isle of Man v West Didsbury & Chorlton | The Bowl | |
| 15:00 | Glossop North End v Pilkington | The Asgard Engineering Stadium | |
| 15:00 | Irlam v FC St Helens | The Silver St Stadium | |
| 15:00 | Longridge Town v Prestwich Heys | Longridge Town FC | |
| 15:00 | Ramsbottom United v Barnoldswick Town | Harry Williams Riverside Stadium | |
| 15:00 | South Liverpool v AFC Liverpool | Jericho Lane | |
| 15:00 | Stockport Town v Padiham | Stockport Sports Village | |
| Saturday 29th March 2025 Premier Division |
| Abbey Hey v Padiham (15:00) |
| Bury v Squires Gate (15:00) |
| Cheadle Town v Burscough (15:00) |
| Litherland REMYCA v Colne (15:00) |
| Longridge Town v Pilkington (15:00) |
| Prestwich Heys v Ramsbottom United (15:00) |
| South Liverpool v Irlam (15:00) |
| Stockport Town v FC St Helens (15:00) |
| West Didsbury & Chorlton v Chadderton (15:00) |
| FC Isle of Man v Lower Breck (18:00) |
| Friday 4th April 2025 Premier Division |
|
| Chadderton v Pilkington (19:45) | |
| Played at Avro | |
| Lower Breck v Litherland REMYCA (20:00) | |
| Saturday 5th April 2025 Premier Division |
| AFC Liverpool v West Didsbury & Chorlton (15:00) |
| Barnoldswick Town v Prestwich Heys (15:00) |
| Burscough v Longridge Town (15:00) |
| Bury v Padiham (15:00) |
| Colne v Cheadle Town (15:00) |
| FC St Helens v South Liverpool (15:00) |
| Irlam v Abbey Hey (15:00) |
| Ramsbottom United v Stockport Town (15:00) |
| Squires Gate v Glossop North End (15:00) |
| FC Isle of Man v Charnock Richard (18:00) |
| Friday 11th April 2025 Premier Division |
| AFC Liverpool v Colne (20:00) |
| Saturday 12th April 2025 Premier Division |
| Abbey Hey v FC St Helens (15:00) |
| Chadderton v Ramsbottom United (15:00) |
| Cheadle Town v Bury (15:00) |
| Glossop North End v Burscough (15:00) |
| Lower Breck v Barnoldswick Town (15:00) |
| Padiham v South Liverpool (15:00) |
| Pilkington v Squires Gate (15:00) |
| Prestwich Heys v Irlam (15:00) |
| Stockport Town v Charnock Richard (15:00) |
| West Didsbury & Chorlton v Longridge Town (15:00) |
| FC Isle of Man v Litherland REMYCA (18:00) |
| Saturday 19th April 2025 Premier Division |
| Bury v Burscough (15:00) |
| Chadderton v Litherland REMYCA (15:00) |
| Charnock Richard v Squires Gate (15:00) |
| Cheadle Town v Lower Breck (15:00) |
| Colne v Abbey Hey (15:00) |
| FC Isle of Man v West Didsbury & Chorlton (15:00) |
| Glossop North End v Pilkington (15:00) |
| Irlam v FC St Helens (15:00) |
| Longridge Town v Prestwich Heys (15:00) |
| Ramsbottom United v Barnoldswick Town (15:00) |
| South Liverpool v AFC Liverpool (15:00) |
| Stockport Town v Padiham (15:00) |
