| Tuesday 26th August 2025 | The Edward Case Cup Preliminary Round North | ||
| 19:45 |  Steeton v Fulwood Amateurs  | Marley Stadium | |
| Tuesday 26th August 2025 | The Edward Case Cup Preliminary Round South | ||
| 19:45 |  Shawbury United v Wolverhampton Sporting Community  | Shawbury Utd Community Sports and Recreational Centre | |
| 20:00 |  Foley Meir v Allscott Heath  | Trentham Foods Stadium | |
| Wednesday 27th August 2025 | The Edward Case Cup Preliminary Round North | ||
| 19:45 |  MSB Woolton v Garstang  | Jericho Lane | |
| Wednesday 27th August 2025 | The Edward Case Cup Preliminary Round South | ||
| 19:45 |  Telford Town v Haughmond  | DRM Aggregate Arena | |
| To Be Confirmed | The Edward Case Cup 1st Round North | ||
| 15:00 |  Ashton Town v Steeton or Fulwood Amateurs | The Bartons Group Stadium | |
| 15:00 |  Bacup Borough v Holker Old Boys  | Brian Boys West View Stadium | |
| 15:00 |  Daisy Hill v Ashton Athletic  | The Ginge Power Stadium | |
| 15:00 |  Darwen FC v Colne  | Multevo Group Anchor Ground | |
| 15:00 |  Droylsden v AFC Blackpool  | The Butchers Arms | |
| 15:00 | Nelson v MSB Woolton or Garstang | Little Wembley | |
| 15:00 |  Squires Gate v Maghull  | The Skiddle Community Stadium | |
| 15:00 |  Thornton Cleveleys v Maine Road  | Gamble Road | |
| TBC | The Edward Case Cup 1st Round South | ||
| 15:00 |  Alsager Town v Sandbach United  | Wood Park | |
| 15:00 |  Ashville v Wolverhampton Casuals  | Ray Parker Stadium | |
| 15:00 | Foley Meir or Allscott Heath v Stockport Georgians | To be confirmed | |
| 15:00 |  New Mills v Cheadle Heath Nomads  | Church Lane | |
| 15:00 |  Runcorn Town v Cammell Laird 1907  | Viridor Community Stadium | |
| 15:00 | Shawbury United or Wolverhampton Sporting Community v Barnton | To be confirmed | |
| 15:00 |  Stafford Town v Market Drayton Town  | Evans Park | |
| 15:00 | Telford Town or Haughmond v Eccleshall | To be confirmed | |
| Tuesday 26th August 2025 The Edward Case Cup Preliminary Round North |
| Steeton v Fulwood Amateurs (19:45) |
| Tuesday 26th August 2025 The Edward Case Cup Preliminary Round South |
| Shawbury United v Wolverhampton Sporting Community (19:45) |
| Foley Meir v Allscott Heath (20:00) |
| Wednesday 27th August 2025 The Edward Case Cup Preliminary Round North |
| MSB Woolton v Garstang (19:45) |
| Wednesday 27th August 2025 The Edward Case Cup Preliminary Round South |
| Telford Town v Haughmond (19:45) |
| TBC The Edward Case Cup 1st Round North |
| Ashton Town v Steeton or Fulwood Amateurs (15:00) |
| Bacup Borough v Holker Old Boys (15:00) |
| Daisy Hill v Ashton Athletic (15:00) |
| Darwen FC v Colne (15:00) |
| Droylsden v AFC Blackpool (15:00) |
| Nelson v MSB Woolton or Garstang (15:00) |
| Squires Gate v Maghull (15:00) |
| Thornton Cleveleys v Maine Road (15:00) |
| TBC The Edward Case Cup 1st Round South |
| Alsager Town v Sandbach United (15:00) |
| Ashville v Wolverhampton Casuals (15:00) |
| Foley Meir or Allscott Heath v Stockport Georgians (15:00) |
| New Mills v Cheadle Heath Nomads (15:00) |
| Runcorn Town v Cammell Laird 1907 (15:00) |
| Shawbury United or Wolverhampton Sporting Community v Barnton (15:00) |
| Stafford Town v Market Drayton Town (15:00) |
| Telford Town or Haughmond v Eccleshall (15:00) |
